run node app with es6features

I use the require hook of BabelJS (formerly named 6to5) to run node apps with es6features:

// run.js
require("babel/register");
require("./app.js6");

I call node run.js to run my app.js6. I need to install BabelJS and provide a run.js for each project I'd like to use es6features. I would prefer a call like nodejs6 app.js6. How can I achieve this system independently (Unix and Windows)?